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SR9009

 Details of SR9009

Superlist Name: SR9009

Molecular Formula: C20H24ClN3O4S

CAS No.: 1379686-30-2 

Purity: 99%

Synonyms: Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate

Molecular Weight: 437.94

Appearance: White powder

Solubility: DMSO

Port: SH 

Application: SR9009 increase exercise endurance and loss weight.

SR9009 is a research drug that was developed by Professor Thomas Burris of the Scripps Research Institute as an agonistof Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ.

Activation of Rev-erb-α by in mice SR9009 increases exercise capacity in mice by increasing mitochondria in skeletal muscle.

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